Following on from my comments regarding the PMDG 737 above, I decided to purchase the PMDG 747 and see how it works in fly inside.
And I surprising found it works better than the PMDG 737. All the interaction points line up when using the interaction dot (blue dot).
I again as per the 737 haven't completed a fill cold and dark start. However I can program the FMC (this is the only bit a bit harder than the 737, as the FMC sits further away in the cockpit and therefore the buttons are slightly harder to read), all cockpit instruments are readable, however I do use zoom in the MFD to see waypoint names to save leaning in to read. and all autopilot controls are easy to work with the interaction dot.
This has now replaced the 737 as my favorite aircraft to fly in FlyInside, well worth the purchase.