I'm going to bump this as it's recurring a lot for me.
I've been trying out Orth4XP so I've been adding scenery and adding / removing entries from my scenery_pack.ini
While I cannot be sure, it certainly feels like every time I modify something this problem returns. The only way to solve the problem when it returns is to reboot which is very annoying.
I have other issues but I'll start a new thread.
As I mentioned above, I have quite a log of plugins but half my problem is that I actually don't remember what they're all for